Jorn Weisner

Dortmund, NW, Germany

Last Updated: 09/26/2026

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Found 23 publications

Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST.

Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST.

Journal: Nature communications

Published: December 08, 2025

Advancing TET Inhibitor Development: From Structural Insights to Biological Evaluation.

Advancing TET Inhibitor Development: From Structural Insights to Biological Evaluation.

Journal: ACS medicinal chemistry letters

Published: January 22, 2025

Synthesis of Asymmetric Ionic Hybrid Detergents enables Micelles with Scalable Properties including Cell Compatibility.

Synthesis of Asymmetric Ionic Hybrid Detergents enables Micelles with Scalable Properties including Cell Compatibility.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: May 10, 2024

Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises.

Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises.

Journal: Journal of medicinal chemistry

Published: April 09, 2024

Correction: A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2.

Correction: A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2.

Journal: RSC medicinal chemistry

Published: January 17, 2024

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.

Journal: Nature communications

Published: July 11, 2023

Insights into the Conformational Plasticity of the Protein Kinase Akt1 by Multi-Lateral Dipolar Spectroscopy.

Insights into the Conformational Plasticity of the Protein Kinase Akt1 by Multi-Lateral Dipolar Spectroscopy.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: December 19, 2022

A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2.

A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2.

Journal: RSC medicinal chemistry

Published: June 17, 2022

Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.

Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.

Journal: Journal of medicinal chemistry

Published: April 29, 2022

Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions.

Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions.

Journal: PloS one

Published: January 18, 2022

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach.

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach.

Journal: ChemMedChem

Published: December 23, 2021

Cellular model system to dissect the isoform-selectivity of Akt inhibitors.

Cellular model system to dissect the isoform-selectivity of Akt inhibitors.

Journal: Nature communications

Published: March 30, 2021

Showing 1-12 of 23

Last Updated: 09/26/2026