Jose A. Ortega

Via Morego 30
Genoa, 16163, Italy

Last Updated: 09/26/2026

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Found 23 publications

A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3β/FYN-α/DYRK1A) Inhibitors.

A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3β/FYN-α/DYRK1A) Inhibitors.

Journal: Journal of medicinal chemistry

Published: April 29, 2026

Exploration of the Neuromodulatory Properties of Fyn and GSK-3β Kinases Exploiting 7-Azaindole-Based Inhibitors.

Exploration of the Neuromodulatory Properties of Fyn and GSK-3β Kinases Exploiting 7-Azaindole-Based Inhibitors.

Journal: Journal of medicinal chemistry

Published: August 08, 2025

Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors.

Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors.

Journal: Scientific reports

Published: April 02, 2025

Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity.

Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity.

Journal: Cell death discovery

Published: October 14, 2024

Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy.

Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy.

Journal: Journal of medicinal chemistry

Published: June 12, 2024

Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer.

Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer.

Journal: Angewandte Chemie (International ed. in English)

Published: August 25, 2023

Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties.

Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties.

Journal: European journal of medicinal chemistry

Published: July 11, 2023

Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer.

Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer.

Journal: Journal of medicinal chemistry

Published: April 07, 2023

Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.

Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.

Journal: European journal of medicinal chemistry

Published: May 20, 2022

Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.

Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.

Journal: Cell reports

Published: April 27, 2022

Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.

Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.

Journal: Angewandte Chemie (International ed. in English)

Published: March 21, 2022

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry.

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry.

Journal: ACS medicinal chemistry letters

Published: February 15, 2022

Showing 1-12 of 23

Last Updated: 09/26/2026