Jose M. De Pereda

Salamanca, CL 37007, Spain

Last Updated: 09/26/2026

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Found 34 publications

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation.

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation.

Journal: Science advances
Published: July 17, 2026

Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity.

Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity.

Journal: Blood
Published: September 16, 2025

C3G deregulation uncovers a dual role in B-cell lymphoma: tumor suppression and enhanced metastasis via Rap1 and Rac2 signaling.

C3G deregulation uncovers a dual role in B-cell lymphoma: tumor suppression and enhanced metastasis via Rap1 and Rac2 signaling.

Journal: Cell communication and signaling : CCS
Published: June 18, 2025

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins.

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins.

Journal: Blood
Published: April 15, 2025

LYP regulates SLP76 and other adaptor proteins in T cells.

LYP regulates SLP76 and other adaptor proteins in T cells.

Journal: Biological research
Published: December 30, 2023

Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets.

Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets.

Journal: mBio
Published: August 01, 2023

Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms.

Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms.

Journal: Cell communication and signaling : CCS
Published: December 12, 2022

Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment.

Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment.

Journal: Blood reviews
Published: October 27, 2022

Regulation of hemidesmosome dynamics and cell signaling by integrin α6β4.

Regulation of hemidesmosome dynamics and cell signaling by integrin α6β4.

Journal: Journal of cell science
Published: September 15, 2021

PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders.

PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders.

Journal: Cellular and molecular life sciences : CMLS
Published: September 14, 2021

C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies.

C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies.

Journal: Molecular & cellular oncology
Published: February 08, 2021

EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines.

EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines.

Journal: Scientific reports
Published: October 07, 2020
Showing 1-12 of 34

Last Updated: 09/26/2026