Joseph A. Trapani

305 Grattan St
Melbourne, VIC, Australia

Last Updated: 09/26/2026

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Found 142 publications

Pharmacological inhibition of perforin dampens CD8+ T cell-mediated beta cell destruction in autoimmune diabetes in mice.

Pharmacological inhibition of perforin dampens CD8+ T cell-mediated beta cell destruction in autoimmune diabetes in mice.

Journal: Diabetologia
Published: March 25, 2026

Differential perforin sensitivity drives lineage-dependent resistance to CAR T-cell killing in blood cancer cell lines.

Differential perforin sensitivity drives lineage-dependent resistance to CAR T-cell killing in blood cancer cell lines.

Journal: Blood advances
Published: January 27, 2026

Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models.

Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models.

Journal: Science translational medicine
Published: October 29, 2025

Cytotoxic lymphocyte effector function is unaffected in patients with Gaucher disease.

Cytotoxic lymphocyte effector function is unaffected in patients with Gaucher disease.

Journal: Frontiers in immunology
Published: August 06, 2025

A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity.

A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity.

Journal: Cell reports
Published: May 22, 2025

Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision.

Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision.

Journal: Science advances
Published: December 18, 2024

Hypoxia and IL-15 Cooperate to Induce Perforin Expression by CD8 T Cells and Promote Damage to the Skin in Murine Cutaneous Leishmaniasis.

Hypoxia and IL-15 Cooperate to Induce Perforin Expression by CD8 T Cells and Promote Damage to the Skin in Murine Cutaneous Leishmaniasis.

Journal: The Journal of investigative dermatology
Published: December 09, 2024

A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation.

A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation.

Journal: Molecular cell
Published: December 01, 2024

Cancer cell-specific PD-L1 expression is a predictor of poor outcome in patients with locally advanced oral cavity squamous cell carcinoma.

Cancer cell-specific PD-L1 expression is a predictor of poor outcome in patients with locally advanced oral cavity squamous cell carcinoma.

Journal: Journal for immunotherapy of cancer
Published: August 27, 2024

Acidic pH can attenuate immune killing through inactivation of perforin.

Acidic pH can attenuate immune killing through inactivation of perforin.

Journal: EMBO reports
Published: July 07, 2024

Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.

Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.

Journal: Frontiers in pharmacology
Published: March 06, 2024

Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity.

Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity.

Journal: Cell reports
Published: December 22, 2023
Showing 1-12 of 142

Last Updated: 09/26/2026