Joseph Avruch

Endocrinology
55 Fruit St
Boston, MA 02114

Last Updated: 09/26/2026

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Found 36 publications

Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.

Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.

Journal: Diabetes
Published: December 06, 2021

RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression.

RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression.

Journal: Molecular metabolism
Published: October 20, 2020

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Journal: Cell
Published: May 10, 2019

Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation.

Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation.

Journal: The Journal of biological chemistry
Published: April 05, 2019

Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates.

Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates.

Journal: F1000Research
Published: December 18, 2018

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.

Journal: Molecular and cellular biology
Published: November 08, 2018

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.

Journal: Nature communications
Published: August 23, 2018

The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.

The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.

Journal: Frontiers in immunology
Published: July 06, 2018

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.

Journal: eLife
Published: March 24, 2017

MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.

MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.

Journal: Biochemistry
Published: September 13, 2016

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Journal: Nature immunology
Published: March 29, 2015

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.

Journal: Cell reports
Published: December 01, 2014
Showing 1-12 of 36

Last Updated: 09/26/2026