Joseph E. Kaserman

Intensive Care Medicine

725 Albany St
Boston, MA 02118

Last Updated: 09/26/2026

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Found 14 publications

AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema.

AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema.

Journal: bioRxiv : the preprint server for biology

Published: April 17, 2026

Thyroid hormone acts independently of the thyroid hormone receptor beta in hepatocytes to improve systemic insulin sensitivity.

Thyroid hormone acts independently of the thyroid hormone receptor beta in hepatocytes to improve systemic insulin sensitivity.

Journal: Hepatology communications

Published: September 02, 2025

Thyroid hormone receptor beta (THRβ1) is the major regulator of T3 action in human iPSC-derived hepatocytes.

Thyroid hormone receptor beta (THRβ1) is the major regulator of T3 action in human iPSC-derived hepatocytes.

Journal: Molecular metabolism

Published: July 23, 2024

Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models.

Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models.

Journal: European thyroid journal

Published: May 24, 2024

Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications.

Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications.

Journal: Orphanet journal of rare diseases

Published: February 21, 2024

Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses.

Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses.

Journal: PLoS pathogens

Published: June 24, 2022

Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity.

Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity.

Journal: Cell reports

Published: May 23, 2022

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes.

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes.

Journal: Stem cell reports

Published: February 16, 2022

Recombinant Lloviu virus as a tool to study viral replication and host responses.

Recombinant Lloviu virus as a tool to study viral replication and host responses.

Journal: PLoS pathogens

Published: September 22, 2021

Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes.

Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: April 23, 2021

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells.

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells.

Journal: Stem cell reports

Published: November 21, 2019

Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery.

Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery.

Journal: Chronic obstructive pulmonary diseases (Miami, Fla.)

Published: February 07, 2019

Showing 1-12 of 14

Last Updated: 09/26/2026