Josephine M. Janssen

Leiden, ZH, Netherlands

Last Updated: 09/26/2026

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Found 23 publications

Selector adeno-associated viral vectors facilitate on-target precise genome editing and purge off-target chromosomal insertions.

Selector adeno-associated viral vectors facilitate on-target precise genome editing and purge off-target chromosomal insertions.

Journal: Trends in biotechnology
Published: June 23, 2025

Precision genome editing using combinatorial viral vector delivery of CRISPR-Cas9 nucleases and donor DNA constructs.

Precision genome editing using combinatorial viral vector delivery of CRISPR-Cas9 nucleases and donor DNA constructs.

Journal: Nucleic acids research
Published: March 15, 2024

Selection-free precise gene repair using high-capacity adenovector delivery of advanced prime editing systems rescues dystrophin synthesis in DMD muscle cells.

Selection-free precise gene repair using high-capacity adenovector delivery of advanced prime editing systems rescues dystrophin synthesis in DMD muscle cells.

Journal: Nucleic acids research
Published: May 05, 2023

High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells.

High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells.

Journal: Molecular therapy. Nucleic acids
Published: December 13, 2022

Precise homology-directed installation of large genomic edits in human cells with cleaving and nicking high-specificity Cas9 variants.

Precise homology-directed installation of large genomic edits in human cells with cleaving and nicking high-specificity Cas9 variants.

Journal: Nucleic acids research
Published: October 03, 2022

Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells.

Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells.

Journal: Nucleic acids research
Published: January 14, 2022

Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery.

Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery.

Journal: Nucleic acids research
Published: May 17, 2021

Precise and broad scope genome editing based on high-specificity Cas9 nickases.

Precise and broad scope genome editing based on high-specificity Cas9 nickases.

Journal: Nucleic acids research
Published: July 06, 2020

High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells.

High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells.

Journal: Cells
Published: January 28, 2020

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses.

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses.

Journal: Cells
Published: September 10, 2019

Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components.

Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components.

Journal: Gene therapy
Published: July 31, 2019

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking.

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking.

Journal: Nucleic acids research
Published: July 26, 2019
Showing 1-12 of 23

Last Updated: 09/26/2026