Julian E. Fuchs

Lensfield Road
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 84 publications

Understanding the Role of H-Bonds in the Stability of Molecular Glue-Induced Ternary Complexes.

Understanding the Role of H-Bonds in the Stability of Molecular Glue-Induced Ternary Complexes.

Journal: Journal of chemical information and modeling

Published: January 23, 2026

Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model.

Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model.

Journal: Journal of medicinal chemistry

Published: August 27, 2025

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.

Journal: Journal of medicinal chemistry

Published: July 25, 2025

Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups.

Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups.

Journal: Journal of medicinal chemistry

Published: July 29, 2024

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control.

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control.

Journal: Nature metabolism

Published: May 22, 2024

Ligandability assessment of the C-terminal Rel-homology domain of NFAT1.

Ligandability assessment of the C-terminal Rel-homology domain of NFAT1.

Journal: Archiv der Pharmazie

Published: November 08, 2023

Ligand 1 H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution.

Ligand 1 H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry

Published: September 06, 2023

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders.

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders.

Journal: Nature communications

Published: August 16, 2023

Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments.

Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments.

Journal: ChemMedChem

Published: December 16, 2022

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.

Journal: Nature communications

Published: March 02, 2022

Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.

Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.

Journal: Nature cancer

Published: July 27, 2021

A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.

A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.

Journal: ChemMedChem

Published: June 24, 2021

Showing 1-12 of 84

Last Updated: 09/26/2026