Julie A. Frearson

Dundee, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 23 publications

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.

Journal: Journal of medicinal chemistry
Published: June 21, 2023

Substituted Aminoacetamides as Novel Leads for Malaria Treatment.

Substituted Aminoacetamides as Novel Leads for Malaria Treatment.

Journal: ChemMedChem
Published: June 01, 2019

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

Journal: Journal of medicinal chemistry
Published: September 13, 2018

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.

Journal: Journal of medicinal chemistry
Published: November 11, 2017

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Journal: Malaria journal
Published: June 20, 2017

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.

Journal: Journal of medicinal chemistry
Published: September 16, 2016

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.

Journal: Journal of medicinal chemistry
Published: June 18, 2016

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Journal: Nature
Published: June 10, 2016

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.

Journal: Cell chemical biology
Published: May 25, 2016

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

Journal: Journal of medicinal chemistry
Published: September 30, 2015

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.

Journal: ChemMedChem
Published: July 10, 2015

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.

Journal: ChemMedChem
Published: July 10, 2015
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Last Updated: 09/26/2026