Julien Chapuis

Lille, France

Last Updated: 09/26/2026

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Found 27 publications

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Journal: bioRxiv : the preprint server for biology
Published: April 03, 2026

Inflammatory stimulus enhances synaptic material uptake by adult APP microglia in a microfluidic neuron-microglia co-culture model.

Inflammatory stimulus enhances synaptic material uptake by adult APP microglia in a microfluidic neuron-microglia co-culture model.

Journal: Journal of neuroinflammation
Published: September 05, 2025

The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer's disease.

The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer's disease.

Journal: Open biology
Published: November 26, 2024

BIN1 and Alzheimer's disease: the tau connection.

BIN1 and Alzheimer's disease: the tau connection.

Journal: Trends in neurosciences
Published: November 14, 2024

Calpain and caspase regulate Aβ peptide production via cleavage of KINDLIN2 encoded by the AD-associated gene FERMT2.

Calpain and caspase regulate Aβ peptide production via cleavage of KINDLIN2 encoded by the AD-associated gene FERMT2.

Journal: Neurobiology of aging
Published: July 04, 2024

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Journal: Nature genetics
Published: May 17, 2024

High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.

High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.

Journal: Current protocols
Published: October 26, 2023

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Journal: Acta neuropathologica communications
Published: October 20, 2021

New insights into the genetic etiology of Alzheimer's disease and related dementias.

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Journal: Nature genetics
Published: June 16, 2021

Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Journal: Molecular psychiatry
Published: January 05, 2021

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells.

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells.

Journal: Science advances
Published: September 27, 2020

Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures.

Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures.

Journal: Brain communications
Published: April 16, 2020
Showing 1-12 of 27

Last Updated: 09/26/2026