Julio H. Castano

Barcelona, CT, Spain

Last Updated: 09/26/2026

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Found 29 publications

CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.

CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.

Journal: Leukemia
Published: August 05, 2025

Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency.

Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency.

Journal: Nature communications
Published: August 27, 2024

Generation of an inducible dCas9-SAM human PSC line for endogenous gene activation.

Generation of an inducible dCas9-SAM human PSC line for endogenous gene activation.

Journal: Frontiers in cell and developmental biology
Published: August 22, 2024

Comparability exercise of critical quality attributes of clinical-grade human mesenchymal stromal cells from the Wharton's jelly: single-use stirred tank bioreactors versus planar culture systems.

Comparability exercise of critical quality attributes of clinical-grade human mesenchymal stromal cells from the Wharton's jelly: single-use stirred tank bioreactors versus planar culture systems.

Journal: Cytotherapy
Published: July 18, 2023

Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency.

Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency.

Journal: Haematologica
Published: November 07, 2022

Generation of heterozygous SAMD9 CRISPR/Cas9-edited iPSC line (ESi086-A-3), carrying p.I1567M mutation.

Generation of heterozygous SAMD9 CRISPR/Cas9-edited iPSC line (ESi086-A-3), carrying p.I1567M mutation.

Journal: Stem cell research
Published: July 18, 2022

The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia.

The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia.

Journal: Cancers
Published: March 03, 2022

Generation of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus.

Generation of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus.

Journal: Frontiers in cell and developmental biology
Published: December 30, 2021

Generation of two heterozygous GATA2 CRISPR/Cas9-edited iPSC lines, R398W and R396Q, for modeling GATA2 deficiency.

Generation of two heterozygous GATA2 CRISPR/Cas9-edited iPSC lines, R398W and R396Q, for modeling GATA2 deficiency.

Journal: Stem cell research
Published: May 27, 2021

Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants.

Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants.

Journal: Human mutation
Published: March 24, 2021

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo.

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo.

Journal: Journal for immunotherapy of cancer
Published: May 07, 2020

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer.

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer.

Journal: Communications biology
Published: March 13, 2020
Showing 1-12 of 29

Last Updated: 09/26/2026