Junhai W. Xiao

Beijing, 100039, China

Last Updated: 09/26/2026

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Found 34 publications

Discovery of Highly Potent and Selective IKZF2 Degraders for Cancer Immunotherapy.

Discovery of Highly Potent and Selective IKZF2 Degraders for Cancer Immunotherapy.

Journal: Journal of medicinal chemistry

Published: April 07, 2026

YXL-13 attenuates virulence in Pseudomonas aeruginosa mutants and clinical isolates by inhibiting quorum sensing regulators LasR and RhlR.

YXL-13 attenuates virulence in Pseudomonas aeruginosa mutants and clinical isolates by inhibiting quorum sensing regulators LasR and RhlR.

Journal: Microbial pathogenesis

Published: October 29, 2025

Design, Synthesis, and Biological Evaluation of Indole Derivatives Targeting LsrK as AI-2 Quorum Sensing Inhibitors.

Design, Synthesis, and Biological Evaluation of Indole Derivatives Targeting LsrK as AI-2 Quorum Sensing Inhibitors.

Journal: Journal of medicinal chemistry

Published: October 08, 2025

Potent Inhibition of Human Betacoronaviruses by a Short Double-Stapled Peptide Mimicking the HR2 Core Region in Viral Spike Protein.

Potent Inhibition of Human Betacoronaviruses by a Short Double-Stapled Peptide Mimicking the HR2 Core Region in Viral Spike Protein.

Journal: Journal of medicinal chemistry

Published: August 22, 2025

Novel Highly Potent c-Met Degraders against a Broad Range of Cancers.

Novel Highly Potent c-Met Degraders against a Broad Range of Cancers.

Journal: Journal of medicinal chemistry

Published: July 16, 2025

A Bifunctional SARS-CoV-2 Entry Inhibitor Targeting the Host Protease TMPRSS2 and Viral Spike Protein HR1 Region.

A Bifunctional SARS-CoV-2 Entry Inhibitor Targeting the Host Protease TMPRSS2 and Viral Spike Protein HR1 Region.

Journal: International journal of molecular sciences

Published: June 09, 2025

Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions.

Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions.

Journal: European journal of medicinal chemistry

Published: May 07, 2025

Design, Synthesis, and Biological Evaluation of Selective STING Synergists That Enhance cGAMP-STING Pathway Activation without Inherent Agonist Activity.

Design, Synthesis, and Biological Evaluation of Selective STING Synergists That Enhance cGAMP-STING Pathway Activation without Inherent Agonist Activity.

Journal: Journal of medicinal chemistry

Published: April 29, 2025

Novel Quaternary Ammonium Salt-Linked STING Agonist Antibody-Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off-Target Toxicity.

Novel Quaternary Ammonium Salt-Linked STING Agonist Antibody-Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off-Target Toxicity.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: February 06, 2025

Discovery of a Double-Stapled Short Peptide as a Long-Acting HIV-1 Inactivator with Potential for Oral Bioavailability.

Discovery of a Double-Stapled Short Peptide as a Long-Acting HIV-1 Inactivator with Potential for Oral Bioavailability.

Journal: Journal of medicinal chemistry

Published: June 18, 2024

Design, Synthesis, and Biological Evaluation of the Quorum-Sensing Inhibitors of Pseudomonas aeruginosa PAO1.

Design, Synthesis, and Biological Evaluation of the Quorum-Sensing Inhibitors of Pseudomonas aeruginosa PAO1.

Journal: Molecules (Basel, Switzerland)

Published: April 02, 2024

Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer.

Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer.

Journal: Small (Weinheim an der Bergstrasse, Germany)

Published: March 25, 2024

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Last Updated: 09/26/2026