Junhong Guan

Gansu Province Key Laboratory Of Environmental Oncology
Lanzhou, 730030, China

Last Updated: 09/26/2026

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Found 9 publications

53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination.

53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination.

Journal: Science advances
Published: May 22, 2026

Single-cell and spatial transcriptomics uncover a THBS2⁺ CAF-KRT17⁺ malignant cell axis drives progression and immunotherapy resistance in pancreatic cancer.

Single-cell and spatial transcriptomics uncover a THBS2⁺ CAF-KRT17⁺ malignant cell axis drives progression and immunotherapy resistance in pancreatic cancer.

Journal: Translational oncology
Published: April 30, 2026

Advances regarding physiological functions and mechanisms of theaflavin‑3,3'‑digallate (Review).

Advances regarding physiological functions and mechanisms of theaflavin‑3,3'‑digallate (Review).

Journal: Molecular medicine reports
Published: September 22, 2025

Targeting UBE2T suppresses breast cancer stemness through CBX6-mediated transcriptional repression of SOX2 and NANOG.

Targeting UBE2T suppresses breast cancer stemness through CBX6-mediated transcriptional repression of SOX2 and NANOG.

Journal: Cancer letters
Published: September 25, 2024

KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC.

KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC.

Journal: Cell reports. Medicine
Published: June 24, 2024

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis.

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: March 18, 2024

PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer.

PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer.

Journal: Cancer research
Published: May 08, 2023

DNA mismatch repair in cancer immunotherapy.

DNA mismatch repair in cancer immunotherapy.

Journal: NAR cancer
Published: March 17, 2023

Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress.

Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress.

Journal: Gastroenterology
Published: July 25, 2022
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Last Updated: 09/26/2026