Kaijiang Xia

State Key Laboratory Of Anti Infective Drug Discovery And Development
Guangzhou, 510006, China

Last Updated: 09/26/2026

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Found 8 publications

Structure-based design of tirabrutinib derivatives as inhibitors of bacterial tryptophanyl-tRNA synthetase.

Structure-based design of tirabrutinib derivatives as inhibitors of bacterial tryptophanyl-tRNA synthetase.

Journal: Bioorganic chemistry

Published: July 17, 2025

Biochemical and structural characterization of chlorhexidine as an ATP-assisted inhibitor against type 1 methionyl-tRNA synthetase from Gram-positive bacteria.

Biochemical and structural characterization of chlorhexidine as an ATP-assisted inhibitor against type 1 methionyl-tRNA synthetase from Gram-positive bacteria.

Journal: European journal of medicinal chemistry

Published: January 14, 2024

An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.

An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.

Journal: Nucleic acids research

Published: February 09, 2023

Discovery, optimization and evaluation of isothiazolo[5,4-b]pyridine derivatives as RIPK1 inhibitors with potent in vivo anti-SIRS activity.

Discovery, optimization and evaluation of isothiazolo[5,4-b]pyridine derivatives as RIPK1 inhibitors with potent in vivo anti-SIRS activity.

Journal: Bioorganic chemistry

Published: April 24, 2022

Ring closure strategy leads to potent RIPK3 inhibitors.

Ring closure strategy leads to potent RIPK3 inhibitors.

Journal: European journal of medicinal chemistry

Published: November 06, 2020

Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury.

Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury.

Journal: Frontiers in cell and developmental biology

Published: September 14, 2020

Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity.

Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity.

Journal: European journal of medicinal chemistry

Published: April 07, 2020

Design, synthesis, and evaluation of novel CXCR4 antagonists based on an aminoquinoline template.

Design, synthesis, and evaluation of novel CXCR4 antagonists based on an aminoquinoline template.

Journal: Bioorganic chemistry

Published: January 19, 2020

Showing 1-8 of 8

Last Updated: 09/26/2026