Karel Chalupsky

Prague, PR, Czech Republic

Last Updated: 09/26/2026

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Found 44 publications

A vegan diet signature from a multi-omics study on different European populations is related to favorable metabolic outcomes.

A vegan diet signature from a multi-omics study on different European populations is related to favorable metabolic outcomes.

Journal: Gut microbes

Published: December 04, 2025

Structural mechanism and inhibitor discovery for DhhP, a Borrelia burgdorferi cyclic di-AMP phosphodiesterase with an Fe/Mn bimetallic center.

Structural mechanism and inhibitor discovery for DhhP, a Borrelia burgdorferi cyclic di-AMP phosphodiesterase with an Fe/Mn bimetallic center.

Journal: Structure (London, England : 1993)

Published: November 03, 2025

Pregnane X receptor antagonist MI-891 reduces hepatic triglycerides in PXR-CAR-CYP3A4/3A7-humanized mice.

Pregnane X receptor antagonist MI-891 reduces hepatic triglycerides in PXR-CAR-CYP3A4/3A7-humanized mice.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: September 30, 2025

Exploring advanced methodologies for NS5 methyltransferase targeted drug discovery.

Exploring advanced methodologies for NS5 methyltransferase targeted drug discovery.

Journal: European journal of medicinal chemistry

Published: September 03, 2025

Rps19 R67∆ mutation creates a model of Diamond-Blackfan anemia and reveals downstream mediators of p53 pathway.

Rps19 R67∆ mutation creates a model of Diamond-Blackfan anemia and reveals downstream mediators of p53 pathway.

Journal: HemaSphere

Published: August 11, 2025

Zanamivir exposure in healthy rats and rats with acute lung injury.

Zanamivir exposure in healthy rats and rats with acute lung injury.

Journal: Annals of medicine

Published: July 20, 2025

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation.

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation.

Journal: Journal of medicinal chemistry

Published: July 12, 2025

Correction: Functional mitochondrial respiration is essential for glioblastoma tumour growth.

Correction: Functional mitochondrial respiration is essential for glioblastoma tumour growth.

Journal: Oncogene

Published: June 04, 2025

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

Journal: Journal of medicinal chemistry

Published: April 22, 2025

Functional mitochondrial respiration is essential for glioblastoma tumour growth.

Functional mitochondrial respiration is essential for glioblastoma tumour growth.

Journal: Oncogene

Published: December 04, 2024

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation.

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation.

Journal: Nature communications

Published: August 04, 2024

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.

Journal: RSC medicinal chemistry

Published: June 10, 2024

Showing 1-12 of 44

Last Updated: 09/26/2026