Karel Guillemyn
Brussels, BRU, Belgium
Last Updated: 09/26/2026
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Found 15 publications
A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.
Journal: Pain
Published: May 01, 2018
Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.
Journal: Angewandte Chemie (International ed. in English)
Published: December 07, 2017
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.
Journal: ACS medicinal chemistry letters
Published: August 23, 2017
Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.
Journal: ACS chemical neuroscience
Published: July 13, 2017
Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Published: November 10, 2016
Efficient one-pot synthesis of amino-benzotriazolodiazocinone scaffolds via catalyst-free tandem Ugi-Huisgen reactions.
Journal: Organic & biomolecular chemistry
Published: April 28, 2016
Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.
Journal: Journal of medicinal chemistry
Published: April 02, 2016
T3P-Promoted, Mild, One-Pot Syntheses of Constrained Polycyclic Lactam Dipeptide Analogues via Stereoselective Pictet-Spengler and Meyers Lactamization Reactions.
Journal: Organic letters
Published: September 01, 2015
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Journal: European journal of medicinal chemistry
Published: October 06, 2014
Structural basis for bifunctional peptide recognition at human δ-opioid receptor.
Journal: Nature structural & molecular biology
Published: September 22, 2014
Structure revision of N-mercapto-4-formylcarbostyril produced by Pseudomonas fluorescens G308 to 2-(2-hydroxyphenyl)thiazole-4-carbaldehyde [aeruginaldehyde].
Journal: Natural product communications
Published: August 14, 2014
Last Updated: 09/26/2026