Karen M. Sze

Hong Kong, HCW, Hong Kong Special Administrative Region

Last Updated: 09/26/2026

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Found 24 publications

Repurposing Resmetirom suppresses MASH-associated hepatocellular carcinoma, with mechanistic implications of MDK/LRP1-mediated metabolic reprogramming and immunosuppression.

Repurposing Resmetirom suppresses MASH-associated hepatocellular carcinoma, with mechanistic implications of MDK/LRP1-mediated metabolic reprogramming and immunosuppression.

Journal: Hepatology (Baltimore, Md.)

Published: September 13, 2025

Targeting sterol O-acyltransferase 1 rewires fatty acid metabolism and uncovers immune vulnerability in hepatocellular carcinoma.

Targeting sterol O-acyltransferase 1 rewires fatty acid metabolism and uncovers immune vulnerability in hepatocellular carcinoma.

Journal: Hepatology (Baltimore, Md.)

Published: June 10, 2025

GPD1L supports glycerol-3-phosphate and triacylglycerol synthesis and promotes tumor progression in HCC.

GPD1L supports glycerol-3-phosphate and triacylglycerol synthesis and promotes tumor progression in HCC.

Journal: Hepatology (Baltimore, Md.)

Published: September 05, 2024

Nuclear localization of BRCA1-associated protein 1 is important in suppressing hepatocellular carcinoma metastasis via CTCF and NRF1/OGT axis.

Nuclear localization of BRCA1-associated protein 1 is important in suppressing hepatocellular carcinoma metastasis via CTCF and NRF1/OGT axis.

Journal: Cell death & disease

Published: August 21, 2024

Disparity landscapes of viral-induced structural variations in HCC: Mechanistic characterization and functional implications.

Disparity landscapes of viral-induced structural variations in HCC: Mechanistic characterization and functional implications.

Journal: Hepatology (Baltimore, Md.)

Published: January 31, 2024

Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma.

Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma.

Journal: Gut

Published: January 11, 2024

Sorted-Cell Sequencing on HCC Specimens Reveals EPS8L3 as a Key Player in CD24/CD13/EpCAM-Triple Positive, Stemness-Related HCC Cells.

Sorted-Cell Sequencing on HCC Specimens Reveals EPS8L3 as a Key Player in CD24/CD13/EpCAM-Triple Positive, Stemness-Related HCC Cells.

Journal: Cellular and molecular gastroenterology and hepatology

Published: October 10, 2023

LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.

LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.

Journal: Hepatology (Baltimore, Md.)

Published: March 07, 2023

Midline 1 interacting protein 1 promotes cancer metastasis through FOS-like 1-mediated matrix metalloproteinase 9 signaling in HCC.

Midline 1 interacting protein 1 promotes cancer metastasis through FOS-like 1-mediated matrix metalloproteinase 9 signaling in HCC.

Journal: Hepatology (Baltimore, Md.)

Published: June 15, 2022

S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.

S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.

Journal: Gut

Published: June 02, 2022

PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner.

PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner.

Journal: Cellular and molecular gastroenterology and hepatology

Published: May 13, 2022

Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma.

Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma.

Journal: Journal of hepatology

Published: September 18, 2021

Showing 1-12 of 24

Last Updated: 09/26/2026