Karim A. Malik

Bristol, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 23 publications

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

Journal: Journal of medicinal chemistry

Published: April 17, 2025

Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.

Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.

Journal: Cancer letters

Published: June 12, 2024

Identifying targetable metabolic dependencies across colorectal cancer progression.

Identifying targetable metabolic dependencies across colorectal cancer progression.

Journal: Molecular metabolism

Published: April 17, 2024

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.

Journal: Molecular oncology

Published: June 07, 2021

Transcriptomic Analyses of MYCN-Regulated Genes in Anaplastic Wilms' Tumour Cell Lines Reveals Oncogenic Pathways and Potential Therapeutic Vulnerabilities.

Transcriptomic Analyses of MYCN-Regulated Genes in Anaplastic Wilms' Tumour Cell Lines Reveals Oncogenic Pathways and Potential Therapeutic Vulnerabilities.

Journal: Cancers

Published: January 08, 2021

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma.

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma.

Journal: Cells

Published: February 10, 2020

PRMT1 promotes neuroblastoma cell survival through ATF5.

PRMT1 promotes neuroblastoma cell survival through ATF5.

Journal: Oncogenesis

Published: December 13, 2019

Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma.

Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma.

Journal: Frontiers in oncology

Published: November 18, 2019

Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes.

Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes.

Journal: Scientific reports

Published: June 12, 2019

Wnt Signaling Is a Major Determinant of Neuroblastoma Cell Lineages.

Wnt Signaling Is a Major Determinant of Neuroblastoma Cell Lineages.

Journal: Frontiers in molecular neuroscience

Published: December 19, 2018

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

Journal: EMBO molecular medicine

Published: August 26, 2018

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma.

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma.

Journal: Neoplasia (New York, N.Y.)

Published: November 27, 2017

Showing 1-12 of 23

Last Updated: 09/26/2026