Karin Overzet-Pike

Leiden, ZH 2300RC, Netherlands

Last Updated: 09/26/2026

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Found 38 publications

ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development.

ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development.

Journal: Cell reports. Medicine
Published: November 03, 2025

RAG1 lentiviral gene therapy restores T-cell development of RAG1-SCID patient cells in artificial thymic organoids.

RAG1 lentiviral gene therapy restores T-cell development of RAG1-SCID patient cells in artificial thymic organoids.

Journal: Blood advances
Published: April 25, 2025

Safety and efficacy of gene therapy for RAG1-deficient SCID.

Safety and efficacy of gene therapy for RAG1-deficient SCID.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: January 22, 2025

Utilizing epigenetic regulators to improve HSC-based lentiviral gene therapy.

Utilizing epigenetic regulators to improve HSC-based lentiviral gene therapy.

Journal: Blood advances
Published: February 29, 2024

Lentiviral Gene Therapy for Mucopolysaccharidosis II with Tagged Iduronate 2-Sulfatase Prevents Life-Threatening Pathology in Peripheral Tissues But Fails to Correct Cartilage.

Lentiviral Gene Therapy for Mucopolysaccharidosis II with Tagged Iduronate 2-Sulfatase Prevents Life-Threatening Pathology in Peripheral Tissues But Fails to Correct Cartilage.

Journal: Human gene therapy
Published: December 12, 2023

Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations.

Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations.

Journal: Frontiers in immunology
Published: July 28, 2023

Tagged IDS causes efficient and engraftment-independent prevention of brain pathology during lentiviral gene therapy for Mucopolysaccharidosis type II.

Tagged IDS causes efficient and engraftment-independent prevention of brain pathology during lentiviral gene therapy for Mucopolysaccharidosis type II.

Journal: Molecular therapy. Methods & clinical development
Published: June 28, 2023

The recombinase activating genes: architects of immune diversity during lymphocyte development.

The recombinase activating genes: architects of immune diversity during lymphocyte development.

Journal: Frontiers in immunology
Published: April 23, 2023

Multi-omic analyses in immune cell development with lessons learned from T cell development.

Multi-omic analyses in immune cell development with lessons learned from T cell development.

Journal: Frontiers in cell and developmental biology
Published: February 10, 2023

Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus.

Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus.

Journal: Science immunology
Published: November 11, 2022

IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings.

IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings.

Journal: International journal of molecular sciences
Published: August 26, 2022

Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis.

Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis.

Journal: Cells
Published: June 23, 2022
Showing 1-12 of 38

Last Updated: 09/26/2026