Karl Edman

AstraZeneca R&D
Moelndal, O 43283, Sweden

Last Updated: 09/26/2026

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Found 26 publications

Mineralocorticoid Receptor Antagonists With an Acylurea as a Key Polar Interaction Motif.

Mineralocorticoid Receptor Antagonists With an Acylurea as a Key Polar Interaction Motif.

Journal: ChemMedChem

Published: November 19, 2025

The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.

The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.

Journal: British journal of clinical pharmacology

Published: December 07, 2023

AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study.

AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study.

Journal: Clinical and translational science

Published: June 12, 2023

Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction".

Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction".

Journal: Journal of medicinal chemistry

Published: January 28, 2023

Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.

Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.

Journal: Journal of medicinal chemistry

Published: December 09, 2022

Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.

Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.

Journal: Nature structural & molecular biology

Published: April 05, 2022

Unraveling the Allosteric Cross-Talk between the Coactivator Peptide and the Ligand-Binding Site in the Glucocorticoid Receptor.

Unraveling the Allosteric Cross-Talk between the Coactivator Peptide and the Ligand-Binding Site in the Glucocorticoid Receptor.

Journal: Journal of chemical information and modeling

Published: June 22, 2021

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.

Journal: The Journal of biological chemistry

Published: August 06, 2020

Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor.

Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor.

Journal: Science advances

Published: March 01, 2020

Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials.

Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials.

Journal: The Lancet. Rheumatology

Published: September 09, 2019

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.

Journal: Journal of medicinal chemistry

Published: January 01, 2019

Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.

Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.

Journal: Journal of medicinal chemistry

Published: February 10, 2018

Showing 1-12 of 26

Last Updated: 09/26/2026