Karl M. Klein

Frankfurt Am Main, HE, Germany

Last Updated: 09/26/2026

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Found 86 publications

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy.

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy.

Journal: Epilepsia

Published: February 25, 2026

Low diagnostic yield of presurgical genetic testing in adult patients with epilepsy.

Low diagnostic yield of presurgical genetic testing in adult patients with epilepsy.

Journal: Epilepsia

Published: February 10, 2026

Can we predict surgical outcomes: A systematic review and critical appraisal of clinical prediction models in epilepsy surgery.

Can we predict surgical outcomes: A systematic review and critical appraisal of clinical prediction models in epilepsy surgery.

Journal: Epilepsia

Published: February 09, 2026

A translational multimodal machine-learning prototype predicting valproate response in epilepsy treatment.

A translational multimodal machine-learning prototype predicting valproate response in epilepsy treatment.

Journal: Epilepsia

Published: January 30, 2026

A translational multimodal machine-learning prototype predicting valproate response in epilepsy treatment.

A translational multimodal machine-learning prototype predicting valproate response in epilepsy treatment.

Journal: medRxiv : the preprint server for health sciences

Published: September 05, 2025

Identification of a Second-Hit Brain Somatic DEPDC5 Variant Supports Causality of a DEPDC5 Germline Variant of Uncertain Significance. Time for a Classification Update?

Identification of a Second-Hit Brain Somatic DEPDC5 Variant Supports Causality of a DEPDC5 Germline Variant of Uncertain Significance. Time for a Classification Update?

Journal: American journal of medical genetics. Part A

Published: April 16, 2025

Detecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy.

Detecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy.

Journal: Epilepsia

Published: September 25, 2024

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment.

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment.

Journal: Epilepsia

Published: August 02, 2024

Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique.

Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique.

Journal: Epilepsia

Published: January 20, 2024

Independent Associations of Incident Epilepsy and Enzyme-Inducing and Non-Enzyme-Inducing Antiseizure Medications With the Development of Osteoporosis.

Independent Associations of Incident Epilepsy and Enzyme-Inducing and Non-Enzyme-Inducing Antiseizure Medications With the Development of Osteoporosis.

Journal: JAMA neurology

Published: June 12, 2023

Brain mosaicism of hedgehog signalling and other cilia genes in hypothalamic hamartoma.

Brain mosaicism of hedgehog signalling and other cilia genes in hypothalamic hamartoma.

Journal: Neurobiology of disease

Published: March 17, 2023

Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes.

Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes.

Journal: medRxiv : the preprint server for health sciences

Published: March 03, 2023

Showing 1-12 of 86

Last Updated: 09/26/2026