Karlheinz Baumann
Basel, BS, Switzerland
Last Updated: 09/26/2026
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Found 28 publications
Pharmacology of nivegacetor (RG6289), a potent and selective gamma secretase modulator in clinical development for the treatment of Alzheimer's disease.
Journal: Frontiers in pharmacology
Published: January 08, 2026
Correction: γ‑Secretase modulator resistance of an aggressive Alzheimer‑causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
Journal: Alzheimer's research & therapy
Published: April 15, 2025
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
Journal: Alzheimer's research & therapy
Published: December 11, 2024
Discovery of Orally Available and Brain Penetrant AEP Inhibitors.
Journal: Journal of medicinal chemistry
Published: December 13, 2023
Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging.
Journal: NeuroImage. Clinical
Published: January 09, 2023
Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.
Journal: Frontiers in aging neuroscience
Published: January 13, 2022
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Journal: Science translational medicine
Published: October 13, 2021
Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.
Journal: Theranostics
Published: June 18, 2021
Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere.
Journal: Journal of medicinal chemistry
Published: July 25, 2020
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease.
Journal: ACS medicinal chemistry letters
Published: March 03, 2020
Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Published: January 30, 2020
Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer's disease iPSC-derived neurons and mice.
Journal: Molecular and cellular neurosciences
Published: June 05, 2019
Last Updated: 09/26/2026