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Last Updated: 09/26/2026

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Found 30 publications

Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria.

Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria.

Journal: Journal of medicinal chemistry
Published: October 28, 2025

Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.

Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.

Journal: Journal of medicinal chemistry
Published: December 23, 2024

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

Journal: Nature communications
Published: December 18, 2024

Single-Dose Drug Development Candidate for Schistosomiasis.

Single-Dose Drug Development Candidate for Schistosomiasis.

Journal: ACS infectious diseases
Published: October 18, 2024

Medium-Ring Keto Bislactams with Antischistosomal Activity.

Medium-Ring Keto Bislactams with Antischistosomal Activity.

Journal: Journal of medicinal chemistry
Published: October 08, 2024

Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.

Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.

Journal: Cell chemical biology
Published: March 04, 2024

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.

Journal: Science translational medicine
Published: December 13, 2023

Antimalarial Dibenzannulated Medium-Ring Keto Lactams.

Antimalarial Dibenzannulated Medium-Ring Keto Lactams.

Journal: ACS infectious diseases
Published: September 11, 2023

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.

Journal: Frontiers in chemistry
Published: January 24, 2022

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.

Journal: Journal of medicinal chemistry
Published: August 26, 2021

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.

Journal: ACS infectious diseases
Published: June 08, 2021

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

Journal: Journal of medicinal chemistry
Published: April 20, 2021
Showing 1-12 of 30

Last Updated: 09/26/2026