Katherine A. De Villiers

Stellenbosch, WC 7602, South Africa

Last Updated: 09/26/2026

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Found 13 publications

Structure-Activity Relationships of 3-Hydroxypropanamidines (HPAs) with Potent In Vivo Antimalarial Activity.

Structure-Activity Relationships of 3-Hydroxypropanamidines (HPAs) with Potent In Vivo Antimalarial Activity.

Journal: Journal of medicinal chemistry

Published: September 08, 2025

Small Molecule Kinase Inhibitors with In Vitro β-Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning.

Small Molecule Kinase Inhibitors with In Vitro β-Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning.

Journal: ChemMedChem

Published: September 04, 2025

Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β-Hematin Formation from Areas of Enrichment.

Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β-Hematin Formation from Areas of Enrichment.

Journal: ChemMedChem

Published: September 04, 2025

A metabolite-based resistance mechanism against malaria.

A metabolite-based resistance mechanism against malaria.

Journal: Science (New York, N.Y.)

Published: June 12, 2025

A Metabolite-Based Resistance Mechanism Against Malaria.

A Metabolite-Based Resistance Mechanism Against Malaria.

Journal: bioRxiv : the preprint server for biology

Published: March 10, 2025

TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance.

TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance.

Journal: Journal of medicinal chemistry

Published: December 26, 2024

Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors.

Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors.

Journal: ChemMedChem

Published: March 16, 2022

Insights into structural and physicochemical properties required for β-hematin inhibition of privileged triarylimidazoles.

Insights into structural and physicochemical properties required for β-hematin inhibition of privileged triarylimidazoles.

Journal: RSC medicinal chemistry

Published: October 03, 2019

Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites.

Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites.

Journal: European journal of medicinal chemistry

Published: August 17, 2018

The Effects of Quinoline and Non-Quinoline Inhibitors on the Kinetics of Lipid-Mediated β-Hematin Crystallization.

The Effects of Quinoline and Non-Quinoline Inhibitors on the Kinetics of Lipid-Mediated β-Hematin Crystallization.

Journal: Langmuir : the ACS journal of surfaces and colloids

Published: July 11, 2017

Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.

Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.

Journal: Dalton transactions (Cambridge, England : 2003)

Published: September 04, 2015

Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents.

Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents.

Journal: ChemMedChem

Published: August 04, 2015

Showing 1-12 of 13

Last Updated: 09/26/2026