Kazufumi Kubota

Hiromachi, 1408710, Japan

Last Updated: 09/26/2026

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Found 15 publications

N-Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors.

N-Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors.

Journal: ACS medicinal chemistry letters

Published: March 06, 2023

Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury.

Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury.

Journal: Frontiers in molecular neuroscience

Published: November 16, 2022

The Novel Gabapentinoid Mirogabalin Prevents Upregulation of α2δ-1 Subunit of Voltage-Gated Calcium Channels in Spinal Dorsal Horn in a Rat Model of Spinal Nerve Ligation.

The Novel Gabapentinoid Mirogabalin Prevents Upregulation of α2δ-1 Subunit of Voltage-Gated Calcium Channels in Spinal Dorsal Horn in a Rat Model of Spinal Nerve Ligation.

Journal: Drug research

Published: October 10, 2022

A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.

A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.

Journal: Bioorganic & medicinal chemistry letters

Published: September 23, 2020

Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity.

Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity.

Journal: Bioorganic & medicinal chemistry

Published: July 09, 2020

Discovery of a Novel Class of State-Dependent NaV1.7 Inhibitors for the Treatment of Neuropathic Pain.

Discovery of a Novel Class of State-Dependent NaV1.7 Inhibitors for the Treatment of Neuropathic Pain.

Journal: Chemical & pharmaceutical bulletin

Published: July 03, 2020

Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor.

Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor.

Journal: Journal of medicinal chemistry

Published: May 12, 2020

Anxiolytic-like effects of mirogabalin, a novel ligand for α2δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fibromyalgia.

Anxiolytic-like effects of mirogabalin, a novel ligand for α2δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fibromyalgia.

Journal: Pharmacological reports : PR

Published: January 28, 2020

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity.

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity.

Journal: Bioorganic & medicinal chemistry letters

Published: March 27, 2019

Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.

Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.

Journal: Bioorganic & medicinal chemistry letters

Published: March 13, 2019

Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models.

Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models.

Journal: Mediators of inflammation

Published: March 08, 2016

A Novel Selective Prostaglandin E2 Synthesis Inhibitor Relieves Pyrexia and Chronic Inflammation in Rats.

A Novel Selective Prostaglandin E2 Synthesis Inhibitor Relieves Pyrexia and Chronic Inflammation in Rats.

Journal: Inflammation

Published: March 01, 2016

Showing 1-12 of 15

Last Updated: 09/26/2026