Keiro Shirotani

Nagasaki, Japan

Last Updated: 09/26/2026

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Found 20 publications

Stepwise Upregulation of Microglial Genes through the Slow Progression of Amyloid Pathology in Alzheimer's Disease Model Mice.

Stepwise Upregulation of Microglial Genes through the Slow Progression of Amyloid Pathology in Alzheimer's Disease Model Mice.

Journal: Biological & pharmaceutical bulletin

Published: September 02, 2026

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.

Journal: Experimental neurology

Published: April 20, 2026

Cell type- and neuronal differentiation-dependent MME 5'UTR splice variants with distinct translational outputs in human cells.

Cell type- and neuronal differentiation-dependent MME 5'UTR splice variants with distinct translational outputs in human cells.

Journal: Journal of biochemistry

Published: November 10, 2025

Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

Journal: Nature medicine

Published: July 27, 2025

Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits.

Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits.

Journal: The Journal of comparative neurology

Published: March 08, 2025

Proline-rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L-dopa-treated mice.

Proline-rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L-dopa-treated mice.

Journal: Neuropsychopharmacology reports

Published: June 29, 2024

Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.

Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.

Journal: Biological & pharmaceutical bulletin

Published: February 25, 2024

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Journal: Life science alliance

Published: February 08, 2024

Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits.

Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits.

Journal: Journal of biochemistry

Published: August 05, 2023

Enhancement of Neprilysin Activity by Natural Polyphenolic Compounds and Their Derivatives in Cultured Neuroglioma Cells.

Enhancement of Neprilysin Activity by Natural Polyphenolic Compounds and Their Derivatives in Cultured Neuroglioma Cells.

Journal: Biological & pharmaceutical bulletin

Published: March 01, 2023

Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients.

Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients.

Journal: Genes to cells : devoted to molecular & cellular mechanisms

Published: December 22, 2022

The role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2.

The role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2.

Journal: Journal of biochemistry

Published: August 03, 2022

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Last Updated: 09/26/2026