Keisuke Shirakura

Osaka, 5650871, Japan

Last Updated: 09/26/2026

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Found 16 publications

Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery.

Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Published: July 22, 2025

Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases.

Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases.

Journal: Communications biology

Published: October 30, 2023

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: January 12, 2023

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

Journal: Science advances

Published: September 21, 2022

Vascular Leakage Prevention by Roundabout 4 under Pathological Conditions.

Vascular Leakage Prevention by Roundabout 4 under Pathological Conditions.

Journal: Biological & pharmaceutical bulletin

Published: October 04, 2021

HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells.

HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells.

Journal: Tissue barriers

Published: May 06, 2021

Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate.

Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Published: April 20, 2021

PRC2 Components Maintain DNA Hypermethylation of the Upstream Promoter and Regulate Robo4 Expression in Endothelial Cells.

PRC2 Components Maintain DNA Hypermethylation of the Upstream Promoter and Regulate Robo4 Expression in Endothelial Cells.

Journal: Biological & pharmaceutical bulletin

Published: April 03, 2020

Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs.

Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs.

Journal: The Journal of pharmacology and experimental therapeutics

Published: August 08, 2018

The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation.

The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation.

Journal: Journal of cell science

Published: May 07, 2018

Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5.

Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5.

Journal: Scientific reports

Published: January 02, 2018

Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation.

Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation.

Journal: Biochemical and biophysical research communications

Published: November 07, 2017

Showing 1-12 of 16

Last Updated: 09/26/2026