Keith Dredge
Brisbane, QLD, Australia
Last Updated: 09/26/2026
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Found 22 publications
Intraoperative drug delivery to hindbrain tumours via an injectable hydrogel is well tolerated and confers survival benefit against atypical teratoid/rhabdoid xenografts.
Journal: Drug delivery and translational research
Published: July 15, 2025
Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors.
Journal: Journal for immunotherapy of cancer
Published: December 14, 2022
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis.
Journal: Translational research : the journal of laboratory and clinical medicine
Published: January 14, 2021
Heparanase Inhibition by Pixatimod (PG545): Basic Aspects and Future Perspectives.
Journal: Advances in experimental medicine and biology
Published: April 11, 2020
Sulfated glycolipid PG545 induces endoplasmic reticulum stress and augments autophagic flux by enhancing anticancer chemotherapy efficacy in endometrial cancer.
Journal: Biochemical pharmacology
Published: January 30, 2020
Correction: The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine.
Journal: Oncotarget
Published: October 15, 2019
Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors.
Journal: Journal for immunotherapy of cancer
Published: April 23, 2018
A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours.
Journal: British journal of cancer
Published: October 03, 2017
Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth.
Journal: Molecular cancer therapeutics
Published: December 22, 2016
Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer.
Journal: Scientific reports
Published: October 05, 2016
Last Updated: 09/26/2026