Ken-ichi Kasahara
Izunokuni, Japan
Last Updated: 09/26/2026
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Found 13 publications
Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects.
Journal: Journal of medicinal chemistry
Published: March 30, 2017
Effects of naftopidil on inhibitory transmission in substantia gelatinosa neurons of the rat spinal dorsal horn in vitro.
Journal: Journal of the neurological sciences
Published: February 23, 2017
Piezo1 expression increases in rat bladder after partial bladder outlet obstruction.
Journal: Life sciences
Published: August 09, 2016
Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects.
Journal: Journal of medicinal chemistry
Published: July 01, 2015
Increased expression of 5-HT(2A) and 5-HT(2B) receptors in detrusor muscle after partial bladder outlet obstruction in rats.
Journal: Biomedical research (Tokyo, Japan)
Published: June 25, 2015
Mast Cell Accumulation and Degranulation in Rat Bladder with Partial Outlet Obstruction.
Journal: Advances in therapy
Published: April 08, 2015
The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats.
Journal: Journal of pharmacological sciences
Published: December 09, 2013
Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP(1) receptor antagonists for treatment of overactive bladder by core structure replacement.
Journal: Bioorganic & medicinal chemistry letters
Published: November 05, 2013
SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters
Published: September 14, 2013
Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters
Published: August 01, 2013
5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats.
Journal: American journal of physiology. Renal physiology
Published: January 25, 2013
Last Updated: 09/26/2026