Kenny Simmen

Beerse, VLG 2340, Belgium

Last Updated: 09/26/2026

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Found 13 publications

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.

Journal: Journal of medicinal chemistry

Published: March 14, 2024

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.

Journal: Journal of medicinal chemistry

Published: June 30, 2023

Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.

Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.

Journal: Nature

Published: June 29, 2022

Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

Journal: Nature

Published: October 21, 2021

A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

Journal: Nature

Published: June 30, 2020

Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice.

Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice.

Journal: PloS one

Published: May 04, 2018

Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.

Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.

Journal: Journal of medicinal chemistry

Published: May 17, 2016

Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor.

Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor.

Journal: Journal of medicinal chemistry

Published: January 23, 2014

Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

Journal: Journal of medicinal chemistry

Published: December 19, 2013

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

Journal: Journal of medicinal chemistry

Published: October 23, 2013

Cell-based antiviral assays for screening and profiling inhibitors against dengue virus.

Cell-based antiviral assays for screening and profiling inhibitors against dengue virus.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: July 04, 2013

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.

Journal: Bioorganic & medicinal chemistry letters

Published: February 28, 2012

Showing 1-12 of 13

Last Updated: 09/26/2026