Kian L. Lee

Singapore, Singapore

Last Updated: 09/26/2026

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Found 33 publications

Mitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia.

Mitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia.

Journal: HemaSphere
Published: March 18, 2026

Prolonged BCR::ABL1 induction in the SCL-tTA mouse recapitulates gene expression signatures and therapeutic vulnerabilities of primary imatinib-resistant chronic myeloid leukaemia.

Prolonged BCR::ABL1 induction in the SCL-tTA mouse recapitulates gene expression signatures and therapeutic vulnerabilities of primary imatinib-resistant chronic myeloid leukaemia.

Journal: Leukemia
Published: July 04, 2025

ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.

ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.

Journal: Cancer research
Published: November 24, 2024

Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types.

Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types.

Journal: Epigenetics
Published: June 10, 2023

A single-cell atlas identifies pretreatment features of primary imatinib resistance in chronic myeloid leukemia.

A single-cell atlas identifies pretreatment features of primary imatinib resistance in chronic myeloid leukemia.

Journal: Blood
Published: June 07, 2022

A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify®.

A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify®.

Journal: Oncogene
Published: February 02, 2022

Validation and refinement of a RUNX1 mutation-associated gene expression signature in blast crisis chronic myeloid leukemia.

Validation and refinement of a RUNX1 mutation-associated gene expression signature in blast crisis chronic myeloid leukemia.

Journal: Leukemia
Published: October 15, 2021

A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.

A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.

Journal: Scientific reports
Published: September 11, 2020

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia.

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia.

Journal: Blood
Published: January 10, 2020

SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia.

SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia.

Journal: Leukemia
Published: July 21, 2019

Hypoxia Regulates MicroRNA Expression in the Human Carotid Body.

Hypoxia Regulates MicroRNA Expression in the Human Carotid Body.

Journal: Advances in experimental medicine and biology
Published: October 26, 2018

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions.

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions.

Journal: Journal of visualized experiments : JoVE
Published: August 21, 2018
Showing 1-12 of 33

Last Updated: 09/26/2026