Kiel J. Hards

Dunedin, OTA 9054, New Zealand

Last Updated: 09/26/2026

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Found 43 publications

Identification of Chemical Scaffolds That Inhibit the Mycobacterium tuberculosis Respiratory Complex Succinate Dehydrogenase.

Identification of Chemical Scaffolds That Inhibit the Mycobacterium tuberculosis Respiratory Complex Succinate Dehydrogenase.

Journal: ACS infectious diseases
Published: September 13, 2024

A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis.

A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis.

Journal: Cell chemical biology
Published: May 08, 2023

Synthesis, Antibacterial Activity, and Nephrotoxicity of Polymyxin B Analogues Modified at Leu-7, d-Phe-6, and the N-Terminus Enabled by S-Lipidation.

Synthesis, Antibacterial Activity, and Nephrotoxicity of Polymyxin B Analogues Modified at Leu-7, d-Phe-6, and the N-Terminus Enabled by S-Lipidation.

Journal: ACS infectious diseases
Published: November 22, 2022

M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments.

M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments.

Journal: Cell reports
Published: September 16, 2022

Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase.

Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase.

Journal: ACS medicinal chemistry letters
Published: August 24, 2022

Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria.

Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria.

Journal: RSC medicinal chemistry
Published: July 29, 2022

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion.

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion.

Journal: eLife
Published: February 04, 2022

Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis.

Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis.

Journal: Journal of medicinal chemistry
Published: October 27, 2021

Deciphering functional redundancy and energetics of malate oxidation in mycobacteria.

Deciphering functional redundancy and energetics of malate oxidation in mycobacteria.

Journal: The Journal of biological chemistry
Published: August 05, 2021

Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases.

Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases.

Journal: Cell reports
Published: July 15, 2021

An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.

An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.

Journal: Communications biology
Published: July 14, 2021

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB.

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB.

Journal: Nature communications
Published: April 29, 2021
Showing 1-12 of 43

Last Updated: 09/26/2026