Kimio Tohyama

Fujisawa, Japan

Last Updated: 09/26/2026

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Found 32 publications

Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development.

Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: November 14, 2025

Drug transporters in drug disposition - highlights from the year 2024.

Drug transporters in drug disposition - highlights from the year 2024.

Journal: Drug metabolism reviews

Published: July 25, 2025

In vitro and in vivo rescue of dopaminergic neurons in Parkinson's disease models after Parkin gene therapy.

In vitro and in vivo rescue of dopaminergic neurons in Parkinson's disease models after Parkin gene therapy.

Journal: Gene therapy

Published: June 12, 2025

TAK-994 mechanistic investigation into drug-induced liver injury.

TAK-994 mechanistic investigation into drug-induced liver injury.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: January 09, 2025

Drug transporters in drug disposition - highlights from the year 2023.

Drug transporters in drug disposition - highlights from the year 2023.

Journal: Drug metabolism reviews

Published: September 02, 2024

Survey of Pharmaceutical Industry's Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group.

Survey of Pharmaceutical Industry's Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: October 25, 2023

Drug transporters in drug disposition - the year 2022 in review.

Drug transporters in drug disposition - the year 2022 in review.

Journal: Drug metabolism reviews

Published: August 30, 2023

Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.

Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: July 18, 2023

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway.

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway.

Journal: Journal of medicinal chemistry

Published: April 30, 2023

TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy.

TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy.

Journal: The Journal of pharmacology and experimental therapeutics

Published: September 15, 2022

Novel insights in drug transporter sciences: the year 2021 in review.

Novel insights in drug transporter sciences: the year 2021 in review.

Journal: Drug metabolism reviews

Published: June 28, 2022

Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.

Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.

Journal: Journal of medicinal chemistry

Published: June 10, 2022

Showing 1-12 of 32

Last Updated: 09/26/2026