Kimiyuki Shibuya

Higashimurayama, 1890022, Japan

Last Updated: 09/26/2026

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Found 13 publications

Syntheses and pharmacokinetic evaluations of four metabolites of 2-(4-(2-((1H-benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis-(methylthio)pyridin-3-yl)acetamide hydrochloride [K-604], an acyl-CoA:cholesterol O-acyltransferase-1 inhibitor.

Syntheses and pharmacokinetic evaluations of four metabolites of 2-(4-(2-((1H-benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis-(methylthio)pyridin-3-yl)acetamide hydrochloride [K-604], an acyl-CoA:cholesterol O-acyltransferase-1 inhibitor.

Journal: Bioorganic & medicinal chemistry

Published: January 15, 2020

Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor.

Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor.

Journal: Journal of medicinal chemistry

Published: November 16, 2018

Discovery of novel spiro[chromane-2,4'-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists.

Discovery of novel spiro[chromane-2,4'-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists.

Journal: Bioorganic & medicinal chemistry letters

Published: June 26, 2018

Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.

Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: March 16, 2018

Optimization of a novel series of potent and orally bioavailable GPR119 agonists.

Optimization of a novel series of potent and orally bioavailable GPR119 agonists.

Journal: Bioorganic & medicinal chemistry letters

Published: April 10, 2017

Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death.

Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death.

Journal: Journal of lipid research

Published: May 16, 2016

Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist.

Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist.

Journal: Bioorganic & medicinal chemistry

Published: April 25, 2016

Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.

Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.

Journal: Bioorganic & medicinal chemistry

Published: February 27, 2016

Crystal structures of (S)-(+)-5-(3-bromo/chloro-4-isopropoxyphen-yl)-5-methyl-imidazolidine-2,4-dione.

Crystal structures of (S)-(+)-5-(3-bromo/chloro-4-isopropoxyphen-yl)-5-methyl-imidazolidine-2,4-dione.

Journal: Acta crystallographica. Section E, Crystallographic communications

Published: November 25, 2015

Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor β-selective agonists.

Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor β-selective agonists.

Journal: Bioorganic & medicinal chemistry letters

Published: December 17, 2014

New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism.

New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism.

Journal: American journal of physiology. Endocrinology and metabolism

Published: November 17, 2014

Design and discovery of 2-oxochromene derivatives as liver X receptor β-selective agonists.

Design and discovery of 2-oxochromene derivatives as liver X receptor β-selective agonists.

Journal: Bioorganic & medicinal chemistry letters

Published: November 07, 2014

Showing 1-12 of 13

Last Updated: 09/26/2026