Kirsty J. Mclean

131 Princess Street
Manchester, ENG M17DN, United Kingdom

Last Updated: 09/26/2026

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Found 43 publications

Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.

Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.

Journal: Journal of medicinal chemistry

Published: July 14, 2025

Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism.

Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism.

Journal: bioRxiv : the preprint server for biology

Published: January 13, 2025

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: December 10, 2022

Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin.

Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin.

Journal: ACS catalysis

Published: August 11, 2022

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).

Journal: European journal of medicinal chemistry

Published: October 25, 2021

A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism.

A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism.

Journal: International journal of molecular sciences

Published: September 13, 2021

Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct.

Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct.

Journal: Journal of medicinal chemistry

Published: October 17, 2019

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors.

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors.

Journal: ChemistryOpen

Published: July 08, 2019

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.

Journal: Bioorganic & medicinal chemistry

Published: January 04, 2019

Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology.

Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology.

Journal: Methods in enzymology

Published: September 04, 2018

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.

Journal: Scientific reports

Published: August 01, 2018

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus.

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus.

Journal: Journal of inorganic biochemistry

Published: March 14, 2018

Showing 1-12 of 43

Last Updated: 09/26/2026