Klaus T. Wanner

Munich, BY 81377, Germany

Last Updated: 09/26/2026

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Found 81 publications

Synthesis and Biological Evaluation of Nipecotic Acid Derivatives with Terminally Double-Substituted Allenic Spacers as mGAT4 Inhibitors.

Synthesis and Biological Evaluation of Nipecotic Acid Derivatives with Terminally Double-Substituted Allenic Spacers as mGAT4 Inhibitors.

Journal: Journal of medicinal chemistry

Published: September 18, 2025

Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

Journal: Angewandte Chemie (International ed. in English)

Published: October 23, 2024

Serum concentrations of levosimendan and its metabolites OR-1855 and OR-1896 in cardiac surgery patients with cardiopulmonary bypass.

Serum concentrations of levosimendan and its metabolites OR-1855 and OR-1896 in cardiac surgery patients with cardiopulmonary bypass.

Journal: Frontiers in cardiovascular medicine

Published: March 24, 2024

Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.

Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.

Journal: Toxicology letters

Published: February 12, 2024

Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs.

Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs.

Journal: Toxicology letters

Published: December 21, 2023

MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.

MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.

Journal: Toxicology letters

Published: November 19, 2023

Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.

Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.

Journal: Toxicology letters

Published: August 01, 2023

Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.

Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.

Journal: European journal of medicinal chemistry

Published: July 28, 2023

Benocyclidine (BTCP) as Non-labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR).

Benocyclidine (BTCP) as Non-labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR).

Journal: ChemMedChem

Published: January 29, 2023

Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.

Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.

Journal: European journal of medicinal chemistry

Published: November 25, 2022

A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.

A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.

Journal: Toxicology letters

Published: October 07, 2022

Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.

Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.

Journal: Nature structural & molecular biology

Published: September 07, 2022

Showing 1-12 of 81

Last Updated: 09/26/2026