Kongkai J. Zhu

Jinan, 250012, China

Last Updated: 09/26/2026

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Found 68 publications

Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma.

Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma.

Journal: European journal of medicinal chemistry

Published: January 01, 2026

Novel indole-based indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors: design, synthesis, and antidepressant evaluation.

Novel indole-based indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors: design, synthesis, and antidepressant evaluation.

Journal: Bioorganic & medicinal chemistry

Published: September 24, 2025

Hotspot pocket-based discovery of urea transporter selective inhibitors.

Hotspot pocket-based discovery of urea transporter selective inhibitors.

Journal: Nature communications

Published: August 21, 2025

Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema.

Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema.

Journal: Cell

Published: July 11, 2025

Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy.

Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy.

Journal: Cell death discovery

Published: April 07, 2025

LigDockTailor: Ligand-specific docking tool matching using multidimensional descriptors.

LigDockTailor: Ligand-specific docking tool matching using multidimensional descriptors.

Journal: Computational biology and chemistry

Published: March 31, 2025

Discovery of anti-tumor small molecule lead compounds targeting the SH3 domain of c-Src protein through virtual screening and biological evaluation.

Discovery of anti-tumor small molecule lead compounds targeting the SH3 domain of c-Src protein through virtual screening and biological evaluation.

Journal: Archives of biochemistry and biophysics

Published: November 19, 2024

Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement.

Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement.

Journal: Molecular cell

Published: September 11, 2024

Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.

Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.

Journal: Cell

Published: May 10, 2024

Azaphilone pigments from the marine-derived Penicillium sclerotium UJNMF 0503 and their neuroprotective potential against H2O2-induced cell apoptosis through modulating PI3K/Akt pathway.

Azaphilone pigments from the marine-derived Penicillium sclerotium UJNMF 0503 and their neuroprotective potential against H2O2-induced cell apoptosis through modulating PI3K/Akt pathway.

Journal: Bioorganic chemistry

Published: February 15, 2024

Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss.

Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss.

Journal: European journal of medicinal chemistry

Published: January 24, 2024

Bioassay-guided discovery and identification of new potent α-glucosidase inhibitors from Morus alba L. and the interaction mechanism.

Bioassay-guided discovery and identification of new potent α-glucosidase inhibitors from Morus alba L. and the interaction mechanism.

Journal: Journal of ethnopharmacology

Published: November 19, 2023

Showing 1-12 of 68

Last Updated: 09/26/2026