Konstantin Helmsauer

Berlin, BE, Germany

Last Updated: 09/26/2026

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Found 10 publications

Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers.

Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers.

Journal: Cancer discovery

Published: November 26, 2024

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy.

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy.

Journal: Pharmacological research

Published: October 20, 2024

Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil.

Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil.

Journal: Genome research

Published: February 15, 2024

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.

Journal: Nature communications

Published: June 07, 2022

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.

Journal: Nature genetics

Published: December 20, 2021

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.

Journal: Nature communications

Published: December 20, 2020

ecDNA hubs drive cooperative intermolecular oncogene expression.

ecDNA hubs drive cooperative intermolecular oncogene expression.

Journal: Nature

Published: November 16, 2020

Publisher Correction: Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Publisher Correction: Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Journal: Nature genetics

Published: February 29, 2020

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.

Journal: Nature communications

Published: December 20, 2019

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Journal: Nature genetics

Published: October 29, 2019

Showing 1-10 of 10

Last Updated: 09/26/2026