Krzysztof Brzozka

Krakow, MA, Poland

Last Updated: 09/26/2026

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Found 27 publications

In vitro hepatocyte uptake-based estimation of tissue partition coefficients of basic compounds for PBPK modeling.

In vitro hepatocyte uptake-based estimation of tissue partition coefficients of basic compounds for PBPK modeling.

Journal: Journal of pharmaceutical sciences

Published: February 04, 2026

Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer.

Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer.

Journal: Scientific reports

Published: March 11, 2025

The Dual PIM/FLT3 Inhibitor MEN1703 Combines Synergistically With Gilteritinib in FLT3-ITD-Mutant Acute Myeloid Leukaemia.

The Dual PIM/FLT3 Inhibitor MEN1703 Combines Synergistically With Gilteritinib in FLT3-ITD-Mutant Acute Myeloid Leukaemia.

Journal: Journal of cellular and molecular medicine

Published: August 05, 2024

Implementation of a novel method for the determination of plasma protein binding of highly bound compounds using the equilibrium dialysis method coupled with extraction to the organic phase and its comparison to known methods.

Implementation of a novel method for the determination of plasma protein binding of highly bound compounds using the equilibrium dialysis method coupled with extraction to the organic phase and its comparison to known methods.

Journal: Journal of pharmaceutical and biomedical analysis

Published: July 25, 2024

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

Journal: The Journal of clinical investigation

Published: April 15, 2024

Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).

Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).

Journal: European journal of drug metabolism and pharmacokinetics

Published: March 27, 2024

Physiologically based pharmacokinetic modeling of CYP2C8 substrate rosiglitazone and its metabolite to predict metabolic drug-drug interaction.

Physiologically based pharmacokinetic modeling of CYP2C8 substrate rosiglitazone and its metabolite to predict metabolic drug-drug interaction.

Journal: Drug metabolism and pharmacokinetics

Published: January 30, 2024

Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran.

Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran.

Journal: Pharmacological reports : PR

Published: January 18, 2024

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.

Journal: Cancer research

Published: April 01, 2021

Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.

Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.

Journal: European journal of medicinal chemistry

Published: September 11, 2020

Release of adenosine-induced immunosuppression: Comprehensive characterization of dual A2A/A2B receptor antagonist.

Release of adenosine-induced immunosuppression: Comprehensive characterization of dual A2A/A2B receptor antagonist.

Journal: International immunopharmacology

Published: August 31, 2020

Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.

Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: July 14, 2020

Showing 1-12 of 27

Last Updated: 09/26/2026