Laiqiang Chen

State Key Laboratory Of Bioactive Molecules And Druggability Assessment
Guangzhou, China

Last Updated: 09/26/2026

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Found 18 publications

Mutant huntingtin disrupts TET1 transcription and alters DNA methylation in a Huntington's disease knock-in pig model.

Mutant huntingtin disrupts TET1 transcription and alters DNA methylation in a Huntington's disease knock-in pig model.

Journal: Cell reports

Published: December 05, 2025

MANF is essential for astrocyte survival in the monkey brain.

MANF is essential for astrocyte survival in the monkey brain.

Journal: Protein & cell

Published: December 01, 2025

Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice.

Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice.

Journal: Autophagy

Published: August 16, 2025

Multimodal brain cell atlas across the adult macaque lifespan.

Multimodal brain cell atlas across the adult macaque lifespan.

Journal: Cell

Published: January 03, 2025

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease.

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease.

Journal: Molecular neurodegeneration

Published: September 09, 2024

TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease.

TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease.

Journal: Science advances

Published: May 17, 2024

Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models.

Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models.

Journal: The Journal of clinical investigation

Published: January 22, 2024

Mutant THAP11 causes cerebellar neurodegeneration and triggers TREM2-mediated microglial activation in mice.

Mutant THAP11 causes cerebellar neurodegeneration and triggers TREM2-mediated microglial activation in mice.

Journal: The Journal of clinical investigation

Published: December 08, 2023

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice.

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice.

Journal: Cell death & disease

Published: September 08, 2023

Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs.

Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs.

Journal: Neurobiology of disease

Published: July 27, 2023

Mutant HTT does not affect glial development but impairs myelination in the early disease stage.

Mutant HTT does not affect glial development but impairs myelination in the early disease stage.

Journal: Frontiers in neuroscience

Published: June 11, 2023

Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.

Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.

Journal: Progress in neurobiology

Published: September 27, 2022

Showing 1-12 of 18

Last Updated: 09/26/2026