Lari Lehtio

Oulu, Finland

Last Updated: 09/26/2026

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Found 95 publications

Correction for Pfannenstiel et al., "Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication".

Correction for Pfannenstiel et al., "Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication".

Journal: mBio
Published: April 14, 2026

Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors.

Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors.

Journal: Acta crystallographica. Section D, Structural biology
Published: March 13, 2026

Protocol for integrated ubiquitination analysis of in vitro E3 ligase-DUB regulation and in vivo ubiquitin chain linkage characterization.

Protocol for integrated ubiquitination analysis of in vitro E3 ligase-DUB regulation and in vivo ubiquitin chain linkage characterization.

Journal: STAR protocols
Published: March 13, 2026

Discovery of thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket.

Discovery of thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket.

Journal: European journal of medicinal chemistry
Published: March 10, 2026

Targeting collagen biosynthesis by small molecules inhibiting the function of the peptide-substrate-binding domain of collagen prolyl 4-hydroxylases.

Targeting collagen biosynthesis by small molecules inhibiting the function of the peptide-substrate-binding domain of collagen prolyl 4-hydroxylases.

Journal: Scientific reports
Published: February 10, 2026

Discovery of Fused Isoquinolinone/Triazole as a Scaffold for Tankyrase and PARP Inhibition.

Discovery of Fused Isoquinolinone/Triazole as a Scaffold for Tankyrase and PARP Inhibition.

Journal: Journal of medicinal chemistry
Published: December 27, 2025

Parallels and crosstalk of ADP-ribosylation and ubiquitination.

Parallels and crosstalk of ADP-ribosylation and ubiquitination.

Journal: Trends in biochemical sciences
Published: November 03, 2025

Biophysical characterization of zinc and DNA binding properties of MRN complex interacting protein.

Biophysical characterization of zinc and DNA binding properties of MRN complex interacting protein.

Journal: Journal of structural biology
Published: October 31, 2025

A FRET-Based High-Throughput Screening Assay for the Discovery of Mycobacterium tuberculosis DNA ADP-Ribosylglycohydrolase DarG Inhibitors.

A FRET-Based High-Throughput Screening Assay for the Discovery of Mycobacterium tuberculosis DNA ADP-Ribosylglycohydrolase DarG Inhibitors.

Journal: ACS infectious diseases
Published: October 30, 2025

Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3.

Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3.

Journal: ACS chemical biology
Published: September 15, 2025

Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP10.

Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP10.

Journal: European journal of medicinal chemistry
Published: July 02, 2025

Automodification of N-terminal serine residues facilitates PARP2 release from DNA.

Automodification of N-terminal serine residues facilitates PARP2 release from DNA.

Journal: The FEBS journal
Published: July 01, 2025
Showing 1-12 of 95

Last Updated: 09/26/2026