Laura A. Lettice

Edinburgh, SCT EH42XU, United Kingdom

Last Updated: 09/26/2026

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Found 21 publications

Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function.

Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function.

Journal: Genes & development

Published: April 01, 2025

Insights into digit evolution from a fate map study of the forearm using Chameleon, a new transgenic chicken line.

Insights into digit evolution from a fate map study of the forearm using Chameleon, a new transgenic chicken line.

Journal: Development (Cambridge, England)

Published: September 08, 2023

Cohesin is required for long-range enhancer action at the Shh locus.

Cohesin is required for long-range enhancer action at the Shh locus.

Journal: Nature structural & molecular biology

Published: November 01, 2021

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development.

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development.

Journal: Frontiers in cell and developmental biology

Published: August 17, 2020

Deletion of CTCF sites in the SHH locus alters enhancer-promoter interactions and leads to acheiropodia.

Deletion of CTCF sites in the SHH locus alters enhancer-promoter interactions and leads to acheiropodia.

Journal: Nature communications

Published: July 22, 2020

Developmentally regulated Shh expression is robust to TAD perturbations.

Developmentally regulated Shh expression is robust to TAD perturbations.

Journal: Development (Cambridge, England)

Published: April 15, 2019

SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells.

SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells.

Journal: Open biology

Published: July 02, 2016

The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression.

The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression.

Journal: Cell reports

Published: June 26, 2016

Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity.

Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity.

Journal: Development (Cambridge, England)

Published: April 28, 2016

Correction: Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.

Correction: Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.

Journal: PLoS genetics

Published: January 09, 2016

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

Journal: The EMBO journal

Published: October 23, 2015

Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.

Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.

Journal: PloS one

Published: October 13, 2015

Showing 1-12 of 21

Last Updated: 09/26/2026