Last Updated: 09/26/2026
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Found 15 publications
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Journal: ACS medicinal chemistry letters
Published: October 11, 2022
An orally available non-nucleotide STING agonist with antitumor activity.
Journal: Science (New York, N.Y.)
Published: December 17, 2019
Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Published: October 02, 2016
Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.
Journal: Journal of medicinal chemistry
Published: June 17, 2014
4-Benzothiazole-7-hydroxyindolinyl diaryl ureas are potent P2Y1 antagonists with favorable pharmacokinetics: low clearance and small volume of distribution.
Journal: ChemMedChem
Published: April 22, 2014
Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.
Journal: Journal of immunology (Baltimore, Md. : 1950)
Published: March 28, 2014
2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters
Published: January 13, 2014
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.
Journal: Bioorganic & medicinal chemistry letters
Published: December 12, 2013
Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.
Journal: Journal of medicinal chemistry
Published: October 30, 2013
Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds.
Journal: Bioorganic & medicinal chemistry letters
Published: September 23, 2013
2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents.
Journal: Bioorganic & medicinal chemistry letters
Published: March 04, 2013
Last Updated: 09/26/2026