Laura Barreiro-Calvo

Bellaterra, CT 08193, Spain

Last Updated: 09/26/2026

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Found 40 publications

Bile acid scaffold engineering reveals an androstane-triol derivative as a potent immunomodulator with therapeutic efficacy in EAE.

Bile acid scaffold engineering reveals an androstane-triol derivative as a potent immunomodulator with therapeutic efficacy in EAE.

Journal: Journal of neuroinflammation

Published: December 22, 2025

An Integrated Biophysical Fragment Screening Approach Identifies Novel Binders of the CD28 Immune Receptor.

An Integrated Biophysical Fragment Screening Approach Identifies Novel Binders of the CD28 Immune Receptor.

Journal: bioRxiv : the preprint server for biology

Published: December 15, 2025

HTS-Oracle: Experimentally validated AI-enabled prioritization for generalizable small molecule hit discovery.

HTS-Oracle: Experimentally validated AI-enabled prioritization for generalizable small molecule hit discovery.

Journal: bioRxiv : the preprint server for biology

Published: December 12, 2025

Discovery of a CHI3L1-Targeted Small Molecule Modulating Neuroinflammation in Alzheimer's Disease via DNA-Encoded Library (DEL) Screening †.

Discovery of a CHI3L1-Targeted Small Molecule Modulating Neuroinflammation in Alzheimer's Disease via DNA-Encoded Library (DEL) Screening †.

Journal: bioRxiv : the preprint server for biology

Published: November 24, 2025

An integrated biophysical fragment screening approach identifies novel binders of the CD28 immune receptor.

An integrated biophysical fragment screening approach identifies novel binders of the CD28 immune receptor.

Journal: Biochemistry and biophysics reports

Published: November 23, 2025

Discovery of a CHI3L1-targeted small molecule modulating neuroinflammation in Alzheimer's disease via DNA-encoded library (DEL) screening.

Discovery of a CHI3L1-targeted small molecule modulating neuroinflammation in Alzheimer's disease via DNA-encoded library (DEL) screening.

Journal: RSC medicinal chemistry

Published: October 20, 2025

Cladribine Preserves Normal Central Nervous System Cellular Activity and Promotes Neuroprotection to Oxidative Stress Damage.

Cladribine Preserves Normal Central Nervous System Cellular Activity and Promotes Neuroprotection to Oxidative Stress Damage.

Journal: International journal of molecular sciences

Published: September 19, 2025

Discovery and Optimization of LAG-3-Targeted Small Molecules via DNA-Encoded Chemical Library (DEL) Screening for Cancer Immunotherapy.

Discovery and Optimization of LAG-3-Targeted Small Molecules via DNA-Encoded Chemical Library (DEL) Screening for Cancer Immunotherapy.

Journal: Journal of medicinal chemistry

Published: August 20, 2025

TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization.

TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization.

Journal: European journal of medicinal chemistry

Published: August 11, 2025

Discovery and validation of LAGi-DEL: A nanomolar LAG-3 inhibitor that reverses immune suppression in tumor-immune co-culture models.

Discovery and validation of LAGi-DEL: A nanomolar LAG-3 inhibitor that reverses immune suppression in tumor-immune co-culture models.

Journal: European journal of medicinal chemistry

Published: August 10, 2025

HTS-Oracle: A Retrainable AI Platform for High-Confidence Hit Identification Across Difficult-to-Drug Targets.

HTS-Oracle: A Retrainable AI Platform for High-Confidence Hit Identification Across Difficult-to-Drug Targets.

Journal: bioRxiv : the preprint server for biology

Published: August 08, 2025

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules.

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules.

Journal: bioRxiv : the preprint server for biology

Published: July 16, 2025

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Last Updated: 09/26/2026