Laura Fumagalli

Antwerpen, VLG, Belgium

Last Updated: 09/26/2026

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Found 14 publications

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS.

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS.

Journal: Aging cell

Published: November 11, 2024

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration.

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration.

Journal: Nature neuroscience

Published: December 15, 2023

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Journal: Molecular neurodegeneration

Published: November 24, 2023

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons.

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons.

Journal: Acta neuropathologica communications

Published: August 28, 2023

C9orf72 hexanucleotide repeat expansions impair microglial response in ALS.

C9orf72 hexanucleotide repeat expansions impair microglial response in ALS.

Journal: Nature neuroscience

Published: October 13, 2022

HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS.

HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS.

Journal: Acta neuropathologica

Published: May 06, 2022

CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.

CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: February 04, 2022

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices.

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices.

Journal: Journal of visualized experiments : JoVE

Published: September 27, 2021

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.

Journal: Science advances

Published: December 23, 2020

Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.

Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.

Journal: Stem cell reports

Published: October 22, 2020

HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.

HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.

Journal: The EMBO journal

Published: July 07, 2020

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.

Journal: Nature communications

Published: February 22, 2019

Showing 1-12 of 14

Last Updated: 09/26/2026