Laura L. Perissinotti
2500 University Drive
Calgary, AB, Canada
Calgary, AB, Canada
Last Updated: 09/26/2026
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Found 14 publications
The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.
Journal: Molecular pharmacology
Published: December 21, 2018
Lipid roles in hERG function and interactions with drugs.
Journal: Neuroscience letters
Published: January 31, 2018
Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.
Journal: Frontiers in physiology
Published: August 30, 2017
Computational membrane biophysics: From ion channel interactions with drugs to cellular function.
Journal: Biochimica et biophysica acta. Proteins and proteomics
Published: May 07, 2017
A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias.
Journal: The Journal of physiology
Published: January 20, 2017
Mapping Ryanodine Binding Sites in the Pore Cavity of Ryanodine Receptors.
Journal: Biophysical journal
Published: September 07, 2016
Computational Models for Understanding of Structure, Function and Pharmacology of the Cardiac Potassium Channel Kv11.1 (hERG).
Journal: Current topics in medicinal chemistry
Published: June 30, 2016
Role of the pH in state-dependent blockade of hERG currents.
Journal: Scientific reports
Published: May 13, 2016
In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".
Journal: Journal of molecular and cellular cardiology
Published: July 23, 2015
Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.
Journal: Journal of molecular and cellular cardiology
Published: October 06, 2014
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Journal: Biophysical journal
Published: April 24, 2014
Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
Journal: Biophysical journal
Published: April 17, 2014
Last Updated: 09/26/2026