Laura O'regan

Leicester, ENG LE19HN, United Kingdom

Last Updated: 09/26/2026

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Found 21 publications

NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3.

NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3.

Journal: Scientific reports

Published: June 12, 2025

EML2 and EML4 splice variants regulate microtubule remodeling during neuronal cell differentiation.

EML2 and EML4 splice variants regulate microtubule remodeling during neuronal cell differentiation.

Journal: The Journal of biological chemistry

Published: March 04, 2025

Microtubule Association of EML4-ALK V3 Is Key for the Elongated Cell Morphology and Enhanced Migration Observed in V3 Cells.

Microtubule Association of EML4-ALK V3 Is Key for the Elongated Cell Morphology and Enhanced Migration Observed in V3 Cells.

Journal: Cells

Published: October 12, 2024

The mesenchymal morphology of cells expressing the EML4-ALK V3 oncogene is dependent on phosphorylation of Eg5 by NEK7.

The mesenchymal morphology of cells expressing the EML4-ALK V3 oncogene is dependent on phosphorylation of Eg5 by NEK7.

Journal: The Journal of biological chemistry

Published: September 22, 2023

Alternative Treatment Options to ALK Inhibitor Monotherapy for EML4-ALK-Driven Lung Cancer.

Alternative Treatment Options to ALK Inhibitor Monotherapy for EML4-ALK-Driven Lung Cancer.

Journal: Cancers

Published: June 21, 2022

EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity.

EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity.

Journal: Molecular cancer research : MCR

Published: November 30, 2021

Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes.

Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes.

Journal: Biology open

Published: September 18, 2021

BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma.

BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma.

Journal: Molecular cancer therapeutics

Published: May 04, 2020

EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.

EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.

Journal: Journal of cell science

Published: December 02, 2019

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

Journal: Science signaling

Published: August 15, 2019

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Journal: Science signaling

Published: August 16, 2018

Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Journal: Cancer research

Published: December 01, 2016

Showing 1-12 of 21

Last Updated: 09/26/2026