Laurence Berthier-Kraus

Oncology R&D Unit
Suresnes, France

Last Updated: 09/26/2026

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Found 14 publications

Cytokine-like protein 1-induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML.

Cytokine-like protein 1-induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML.

Journal: Blood

Published: August 18, 2020

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.

Journal: Investigational new drugs

Published: March 14, 2020

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL.

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL.

Journal: Blood advances

Published: December 30, 2019

Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma.

Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma.

Journal: Haematologica

Published: July 20, 2019

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: November 27, 2018

Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice.

Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice.

Journal: The Journal of pharmacology and experimental therapeutics

Published: June 30, 2018

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia.

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia.

Journal: Leukemia

Published: June 05, 2018

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

Journal: Oncotarget

Published: September 12, 2017

Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma.

Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma.

Journal: Gene

Published: November 23, 2015

Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.

Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.

Journal: Journal of medicinal chemistry

Published: November 01, 2014

Treatment of nasopharyngeal carcinoma cells with the histone-deacetylase inhibitor abexinostat: cooperative effects with cis-platin and radiotherapy on patient-derived xenografts.

Treatment of nasopharyngeal carcinoma cells with the histone-deacetylase inhibitor abexinostat: cooperative effects with cis-platin and radiotherapy on patient-derived xenografts.

Journal: PloS one

Published: November 08, 2013

The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression.

The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: October 22, 2013

Showing 1-12 of 14

Last Updated: 09/26/2026