Laurent Pradier

Sanofi R&D
Chilly, France

Last Updated: 09/26/2026

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Found 25 publications

Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.

Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.

Journal: Cell reports

Published: December 11, 2025

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies.

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies.

Journal: NPJ Parkinson's disease

Published: October 16, 2024

Participating in innovative medicines initiative funded neurodegenerative disorder projects-An impact analysis conducted as part of the NEURONET project.

Participating in innovative medicines initiative funded neurodegenerative disorder projects-An impact analysis conducted as part of the NEURONET project.

Journal: Frontiers in neurology

Published: January 09, 2023

Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

Journal: Glia

Published: August 18, 2022

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.

Journal: Acta neuropathologica communications

Published: August 05, 2022

The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks.

The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks.

Journal: Frontiers in neurology

Published: July 14, 2022

Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells.

Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells.

Journal: Glia

Published: March 03, 2022

A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer's disease brain.

A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer's disease brain.

Journal: Brain : a journal of neurology

Published: July 12, 2021

A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models.

A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models.

Journal: The Journal of pharmacology and experimental therapeutics

Published: March 03, 2021

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia.

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia.

Journal: Scientific reports

Published: November 10, 2020

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model.

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model.

Journal: Molecular therapy. Methods & clinical development

Published: May 20, 2020

Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease.

Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease.

Journal: PloS one

Published: July 17, 2019

Showing 1-12 of 25

Last Updated: 09/26/2026