Lechuang Chen

Laboratory Of Cell And Molecular Biology & State Key Laboratory Of Molecular Oncology, Chinese Academy Of Medical Sciences And Peking Union Medical College
Beijing, China

Last Updated: 09/26/2026

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Found 11 publications

Celastrol acts as a new histone deacetylase inhibitor to inhibit colorectal cancer cell growth via regulating macrophage polarity.

Celastrol acts as a new histone deacetylase inhibitor to inhibit colorectal cancer cell growth via regulating macrophage polarity.

Journal: Cell biology international

Published: May 23, 2022

LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer.

LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer.

Journal: Therapeutic advances in medical oncology

Published: August 28, 2018

IL-6 influences the polarization of macrophages and the formation and growth of colorectal tumor.

IL-6 influences the polarization of macrophages and the formation and growth of colorectal tumor.

Journal: Oncotarget

Published: August 02, 2017

TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis.

TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis.

Journal: Bioscience reports

Published: April 25, 2016

Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells.

Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells.

Journal: Oncotarget

Published: March 15, 2016

The levels of serine proteases in colon tissue interstitial fluid and serum serve as an indicator of colorectal cancer progression.

The levels of serine proteases in colon tissue interstitial fluid and serum serve as an indicator of colorectal cancer progression.

Journal: Oncotarget

Published: January 27, 2016

Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway.

Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway.

Journal: Oncotarget

Published: November 20, 2015

Methylseleninic acid activates Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell carcinoma cells.

Methylseleninic acid activates Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell carcinoma cells.

Journal: Bioscience reports

Published: April 13, 2015

P21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression.

P21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression.

Journal: PloS one

Published: July 02, 2014

Upregulation of KLF4 by methylseleninic acid in human esophageal squamous cell carcinoma cells: Modification of histone H3 acetylation through HAT/HDAC interplay.

Upregulation of KLF4 by methylseleninic acid in human esophageal squamous cell carcinoma cells: Modification of histone H3 acetylation through HAT/HDAC interplay.

Journal: Molecular carcinogenesis

Published: December 20, 2013

Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma.

Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma.

Journal: PloS one

Published: April 19, 2012

Showing 1-11 of 11

Last Updated: 09/26/2026